Until now, organoid applications have been hampered by their dependence on animal-derived hydrogels, which are unsuitable for large-scale applications. The breakthrough innovation of synthetically specialised extracellular matrixes is about to transform the next generation of drug discovery
The last 10 years have seen a dramatic surge in the number of publications about organoids – but what are they and why is everyone talking about them? In simple terms, they are miniature organs grown in vitro, in a near-physiological 3D environment. Unlike simple tissue cultures, they retain features of the organ they are derived from, including important structural and functional properties, and many believe that they could dramatically accelerate the understanding of human biology and disease progression.
Traditional, 2D cell culture has brought great progress in understanding human development over the last 50 years. However, studying organogenesis in vitro has been hindered by the lack of appropriate systems that would allow the cell-to-cell interactions needed for organ formation. Organoids provide the accurate and physiologically relevant models that are needed to overcome this deficiency…….
Download full article here: Access Full EBR Article
Back to News and Media