Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as ‘occult cancer‘. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.
Nat Med. 2011 Mar;17(3):320-9.
Bissell MJ, Hines WC.
The Scientist, February 22, 2018
Nature Medicine. Sept 2017; Vol 23, Nr 9: 1028-1035
Cell. 2018 Jan 11;172(1-2):373-386.
Trends Mol Med. 2017 May;23(5):393-410.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6831-E6839.
Nature. 2016 Nov 24;539(7630):560-564.
Subscribe to our newsletter
Stay up-to-date on the latest advancements in 3D cell culture technology