The science
behind QGel

The Extracellular Matrix (ECM), the gel-like substance that surrounds cells inside the human body, plays a critical role in regulating tissue development and homeostasis. The ECM provides a scaffold for tissue organization as well as biological and biochemical cues that direct cell behavior. Changes in these conditions (growth factors, cytokines, aberrant proteases, hormones, tissue architecture, etc) affect cell proliferation, growth suppression, apoptosis resistance, chronic inflammation, and cell invasion initiation which in turn influences the healthy or diseased-state of the patient.

The innovation of QGel is a novel method to synthetically create specialized ECMs that provide the necessary biological, biochemical and structural support to promote the physiologically accurate behavior of any cell type. This equips:
a) Drug developers with in vitro disease models that more closely approximate the human situation; and
b) Oncologists with improved clinical decision making tools for therapy recommendations.

science behind science behind

Select Conditions Below

OBJECTIVE1

Recapitulating In Vivo Features
in an In Vitro Platform
QGel Assays

Each QGel Advanced 3D Cell Based Assay is designed to support cell growth as well as the natural expression of the desired key features to be recapitulated (target or phenotype)

DESIGNING SYNTHETIC ECMS2

The QGel toolbox of
ECM components

Inspired by nature

QGel deconstructs naturally occuring ECM macromolecules (Fibronectins, Laminins, Collagens, etc) into functional protein subunits that become the building blocks to create unique, synthetic Extracellular Matrices (ECMs)

invitro
Biological

Integrin binding sites, cell-cell binding sites, growth factors, etc

invitro
Biophysical

Matrix stiffness properties

invitro
Biochemical

Degradation properties, e.g. cell-mediated enzymatic degradation, self degrading (fast or slow), etc

QGEL ECM LIBRARY3

Extensive collection
of synthetic ECMs

These building blocks have been assembled in many different combinations to create an extensive library of synthetic ECM formulations. Watch the video below to learn how QGel screens its library to identify a unique formulation capable of supporting cell growth while maintaining the key features for any cell type.

Watch ECM screening process
QGel
Designing an ECM
ecm
Discover the right ECM design for this cell type

QGel's synthetic ECMs technology provides the ability to tune key factors of the ECM until the right combination is identified that supports physiologically accurate cell behavior.
Move the sliders above to see how the ECM can be tuned. At the right combination, the physiological feature will be expressed. Click the Discover button at the top to find the right combination for this particular cell type.

2018 September 10-13
EMBO | EMBL Symposium. Organoids: Modelling Organ Development and Disease in 3D Culture

Heidelberg, Germany

Will you be at the EMBO | EMBL Organoid Symposium in Heidelberg?  Contact us below if you would like to meet someone from the QGel team.

2018 September 21-24
AACR | Pancreatic Cancer: Advances in Science and Clinical Care

Boston, MA

Will you be at the AACR conference in Boston, MA?  Contact us below if you would like to meet someone from the QGel team

2018 September 27-30
AACR | Intestinal Stem Cells and Colon Cancer: Biology to Therapy

Washington, DC

Will you be at the AACR Conference in Washington, DC?  Contact us below if you would like to meet someone from the QGel team

2018 November 5-7
EACR: Precision Medicine

Bergamo, Italy

Will you be at the EACR conference in Bergamo, Italy?  Contact us below if you would like to meet someone from the QGel team

2018 November 15-17
AACR | Precision Medicine in Solid Tumors

Seoul, South Korea

Will you be at the AACR Conference in Seoul, South Korea?  Contact us below if you would like to meet someone from the QGel team

QGel
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