Study effects of different microenvironment on cell line growth

Study Design

• 1 lung cancer cell line H2052
• Goal: Identify how different ECM components influence proliferation

ECM QGel Design

• Multiple QGel 3D Matrices screened to identify best synthetic ECM and culture conditions


• Proliferation of cell line H2052 was driven by QGel ECMs that did not contain integrin binding sites


Data – Results


Proliferation measured by metabolic activity over 28 days

For this cell line, and counter-intuitively, Integrin binding sites inhibit cell growth





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