The 2009 publication, ‘Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche’ by Sato et. al. was a breakthrough achievement for Organoid applications. This work required the use of Matrigel.
To create a synthetic alternative to laminin-rich gels to achieve the same results
In 2016, Lutolf et al published in Nature the successful accomplishment of this goal
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