BROCHURE DOWNLOAD
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QGEL™ PATENTS
QGel™ has a strong patent portfolio of granted patents, that covers the aspects of QGel's product combination for research
and diagnostic applications including :
-Bioengineering QGel™ as a synthetic matrix
-The binding of biomolecules to QGel™
-The release of growth factors bound to QGel™
-The incorporation of drugs into QGel™
PUBLICATIONS
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture, Gilbert PM, Havenstrite KL, Magnusson KEG, Sacco A, Leonardi NA, Kraft P, Nguyen NK, Thrun S, Lutolf MP, Blau HM, Science 27 August 2010:Vol. 329. no. 5995, pp. 1078 - 1081. DOI: 10.1126 / science.1191035
Biomaterials offer cancer research the third dimension, Dietmar W. Hutmacher, Nature Materials 9, 90 - 93 (2010) DOI: doi:10.1038/nmat2619
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells., Loessner D, Stok KS, Lutolf MP, Hutmacher DW, Clements JA, Rizzi SC, Biomaterials, Epub ahead of print (Aug 13 2010).
The effect of matrix characteristics on fibroblast proliferation in 3D gels., Bott K, Upton Z, Schrobback K, Ehrbar M, Hubbell JA, Lutolf MP, Rizzi SC, Biomaterials, Epub ahead of print (Aug 2 2010).
Designing materials to direct stem-cell fate, Lutolf, M.P.*, Gilbert, P.M., and Blau, H.M.*, Nature, 462, 433-441 (2009)
Capturing complex protein gradients on biomimetic hydrogels for cell-based assays, Cosson, S., Kobel, S. and Lutolf, M.P., Advanced Functional Materials, 19 (21), 3411-3419 (2009)
Biomaterials: Spotlight on hydrogels, M.P. Lutolf, Nature Materials, 8, 451 - 453 (2009)
Micropatterning of hydrogels by soft embossing, S. Kobel, M. Limacher, S, Gobaa, T. Laroche, M.P. Lutolf*, Langmuir, DOI: 10.1021/la9002115 (2009)
Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche., Lee ST, Yun JI, Jo YS, Mochizuki M, van der Vlies AJ, Kontos S, Ihm JE, Lim JM, Hubbell JA., Biomaterials, 31(6), 1219-1226 (2010)
Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis, Y.S. Jo, F. Gantz, J.A. Hubbell, M.P. Lutolf*, Soft Matter, 5, 440-446 (2009)
Artificial ECM: expanding the cell biology toolbox in 3D, M.P. Lutolf, Integr. Biol., 1, 235 - 241 (2009)
Perturbation of Single Hematopoietic Stem Cell Fates in Artificial Niches, Lutolf, M.P.*, Doyonnas, R., Havenstrite, K., Koleckar, K., Blau, H.M.*, Integr. Biol., 1, 59 (2009)
Enhancing the Reliability and Throughput of Neurosphere Culture on Hydrogel Microwell Arrays, Stem Cells, M. Cordey, M. Limacher, S. Kobel, V. Taylor, M.P. Lutolf, Stem Cells, doi:10.1634/stemcells.2008-0498
The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype., Adelöw C, Segura T, Hubbell JA, Frey P.,Biomaterials. Jan;29(3):314-26 (2008).
Biomolecular Hydrogels Formed and Degraded via Site-Specific Enzymatic Reactions, M. Ehrbar, S.C. Rizzi, R.G. Schoenmakers, B. San Miguel, J.A. Hubbell, F.E. Weber, and M.P. Lutolf, Biomacromolecules, 8 (10), 3000 -3007 (2007)
Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering, M. Ehrbar, S.C. Rizzi, R. Hlushchuk, V. Djonov, A.H. Zisch, J.A. Hubbell, F.E. Weber, and M.P. Lutolf, Biomaterials 28(26), 3856-3866 (2007)
Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs, G.P. Raeber, M.P. Lutolf*, and J.A. Hubbell, Acta Biomater. 2007 Jun 13; [Epub ahead of print]
Use of a Parathyroid Hormone Peptide (PTH1-34)-enriched hydrogel for the treatment of a subchondral cystic lesion in the proximal interphalangeal joint of a warmblood filly: A case report. Fuerst A, Derungs S, von Rechenberg B, Auer JA, Schense, J, Watson J., J. Vet. Med. 2006; 53:1-6.
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering, M.P. Lutolf* and J.A. Hubbell* , Nature Biotechnology, 23 (1): 47-55 (2005)
Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration, G.P. Raeber, M.P. Lutolf, and J.A. Hubbell, Biophysical Journal, Aug; 89 (2): 1374-1388 (2005)
Cell-demanded release of VEGF from synthetic, biointeractive cell-ingrowth matrices for vascularized tissue growth, A.H. Zisch*, M.P. Lutolf*, M. Ehrbar, G.P. Raeber, V. Djonov, D. Bezuidenhout, N. Davis, H. Schmoekel, P. Zilla, and J.A. Hubbell (* equal contribution), FASEB 17(15), 2260-2262 (2003)
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices, M.P. Lutolf, F.E. Weber, H. Schmoekel, J.C. Schense, T. Kohler, R. Mueller, and J.A. Hubbell, Nature Biotechnology 21, 513-518 (2003)
Synthetic MMP-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics, M.P. Lutolf, J.L. Lauer-Fields, H. Schmoekel, A.T. Metters, F.E. Weber, H. Nagase, G.B. Fields, and J.A. Hubbell, Proc. Natl. Acad. Sci. USA 100 (9), 5413-5418 (2003)
Cell-responsive synthetic hydrogels, M.P. Lutolf, G.P. Raeber, A.H. Zisch, N. Tirelli, and J.A. Hubbell , Advanced Materials 15 (11), 888-892 (2003)
Water-borne, in situ crosslinked biomaterials from phase-segregated precursors, Vernon B, Tirelli N, Bachi T, Haldimann D, Hubbell JA, J Biomed Mater Res. 2003 Mar 1;64A(3):447-56.
Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering, Biomacromolecules. Elbert DL, Hubbell JA. 2001 Summer;2(2):430-41.
Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids. Lutolf MP, Tirelli N, Cerritelli S, Cavalli L, Hubbell JA. Bioconjug Chem. 2001 Nov-Dec;12(6):1051-6.
Protein delivery from materials formed by self-selective conjugate addition reactions J Control Release. Elbert DL, Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA. 2001 Sep 11;76(1-2):11-25.
Development of growth factor fusion proteins for cell-triggered drug delivery. Sakiyama-Elbert SE, Panitch A, Hubbell JA. FASEB J. 2001 May;15(7):1300-2. No abstract available.